Pathway to Successful Young Adulthood

The Pathway to Successful Young Adulthood assembles a wealth of findings from research, practice, theory, and policy about what it takes to improve the lives of children, youth and families, particularly those living in tough neighborhoods. By laying out a comprehensive, coherent array of actions, the Pathway informs efforts to improve community conditions within supportive policy and funding contexts. The Pathways framework does not promote a single formula or program. Rather, our emphasis is on acting strategically across disciplines, systems, and jurisdictions to increase the number of young people who make a successful transition to young adulthood. The Pathway provides a starting point to guide choices made by community coalitions, services providers, researchers, funders, and policymakers to achieve desired outcomes for young people and their families

Comparitive assessment of the vulnerability and resilience of 10 deltas, synthesis report

The proposed framework for delta assessment and especially the scorecards are intended to enhance awareness raising, discussion and prioritization on most relevant delta issues, in each delta but also in comparison with other deltas. This should lead to more efficient and effective (multi-sectoral) policy formulation, management design and implementation, in concrete Delta plans, pilot-projects and (research) programmes. The target groups are all stakeholders who are involved in delta management at different levels and with different interests (government, private companies, NGOs, public), and who wish to contribute to the resilience of their own delta and other deltas worldwide

Comparative assessment of the vulnerability and resilience of 10 deltas : work document

Background information about: Nile delta (Egypt), Incomati delta (Mozambique), Ganges-Brahmaputra-Meghna (Bangladesh), Yangtze (China), Ciliwung (Indonesia), Mekong (Vietnam), Rhine-Meuse (The Netherlands), Danube (Romania), California Bay-Delta, Mississippi River Delta (USA

Synaptic nanomodules underlie the organization and plasticity of spine synapses.

Experience results in long-lasting changes in dendritic spine size, yet how the molecular architecture of the synapse responds to plasticity remains poorly understood. Here a combined approach of multicolor stimulated emission depletion microscopy (STED) and confocal imaging in rat and mouse demonstrates that structural plasticity is linked to the addition of unitary synaptic nanomodules to spines. Spine synapses in vivo and in vitro contain discrete and aligned subdiffraction modules of pre- and postsynaptic proteins whose number scales linearly with spine size. Live-cell time-lapse super-resolution imaging reveals that NMDA receptor-dependent increases in spine size are accompanied both by enhanced mobility of pre- and postsynaptic modules that remain aligned with each other and by a coordinated increase in the number of nanomodules. These findings suggest a simplified model for experience-dependent structural plasticity relying on an unexpectedly modular nanomolecular architecture of synaptic proteins

HM 2: Charleston Blockade: The Journals of John B. Marchand, U.S. Navy 1861-1862

Students of the American Civil War, whose ranks are legion, have paid vigorous attention to the many facets of the Union blockade of the Southern Confederacy. Questions of its strategic and economic impact are frequently debated, as are the important problems of logistics and diplomacy. Relatively little attention, however, has been paid to the participants themselves. The men who served on the blockading ships of the U.S. Navy performed the most tedious, if not the most perilous, task of the war. This volume is about one of them: Comdr. John Bonnet Marchand, USN.https://digital-commons.usnwc.edu/usnwc-historical-monographs/1001/thumbnail.jp

Behavior of macrophage and osteoblast cell lines in contact with the β-TCP biomaterial (beta-tricalcium phosphate)

Beta-tricalcium phosphate (β-TCP) is a synthetic ceramic used for filling bone defects. It is a good alternative to autologous grafts since it is biocompatible, resorbable and osteoconductive. Previous in vivo studies have shown that macrophages are one of the first cells coming in contact with the biomaterial followed by osteoclasts and osteoblasts that will elaborate new bone packets. Studies have focused on osteoclast morphology and very few of them have investigated the role of macrophages. The aims of this study were to characterize (i) the biomaterial surface; (ii) the in vitro behavior of macrophages (J774.2 and Raw264.7 cells) using the description of cell morphology by scanning electron microscopy (SEM) at 7 and 14 days; (iii) the behavior of osteoblasts (SaOs-2 and MC3T3-E1 cells) seeded at the surface of the biomaterial 24, 48 and 72hours by SEM and confocal microscopy. Cell proliferation was analyzed by MTT assays. Viability and affinity of the macrophages for β-TCP were found significantly increased after 7 and 14d. MC3T3-E1 cells were anchored and stretched onto the β-TCP surface as early as 24h with a high proliferation rate (+190%) when compared to the surface of a well plate. SaOs-2 exhibited the same morphological profile at 72h. Proliferation became significantly higher compared to the plastic surface at only 72h (+129%). This study emphasises the importance of choice of the cell line used in exploring the osteoconductive and osteoinductive properties of a biomaterial. Additional studies are needed to analyze differentiation of macrophages into giant multinucleated cells and how the biomaterial surface influences osteoblast differentiation

HM 2: Charleston Blockade: The Journals of John B. Marchand, U.S. Navy 1861-1862

Students of the American Civil War, whose ranks are legion, have paid vigorous attention to the many facets of the Union blockade of the Southern Confederacy. Questions of its strategic and economic impact are frequently debated, as are the important problems of logistics and diplomacy. Relatively little attention, however, has been paid to the participants themselves. The men who served on the blockading ships of the U.S. Navy performed the most tedious, if not the most perilous, task of the war. This volume is about one of them: Comdr. John Bonnet Marchand, USN.https://digital-commons.usnwc.edu/usnwc-historical-monographs/1001/thumbnail.jp

The contemporary landscape of fuel poverty research

A key aim of this special issue has been to showcase the breadth of approaches to fuel poverty research emanating from a growing international community of fuel poverty researchers and in doing so, to promote awareness of the range of disciplinary areas influencing contemporary fuel poverty research. Overcoming established disciplinary and methodological siloes represents a considerable challenge for the future of the field and may be key to offering those in policy and practice the clarity and comprehensive insights that they need to fully understand and respond effectively to the problem